Dealing with cat urine accidents outside the litter box can be frustrating. Not only are the stains unsightly, but the lingering odor can be unpleasant and encourage repeat offenses from your feline friend. The key to effectively removing cat urine stains and odors lies in using the right type of cleaner: a Cat Urine Cleaner With Enzymes.
Enzymatic cleaners are specifically formulated to break down the complex components of cat urine at a molecular level, eliminating both the stain and the odor completely. This is crucial because if any odor remains, even if undetectable to the human nose, your cat’s sensitive sense of smell can lead them back to the same spot for future accidents.
We’ve rigorously tested a wide range of stain and odor removers in our lab and at home with real cats and their owners to identify the best cat urine cleaners with enzymes available. Our top picks effectively tackle both fresh and set-in stains on various surfaces, ensuring your home stays clean and odor-free.
Our Top Picks for the Best Cat Urine Cleaner with Enzymes:
- Best Overall: Bubba’s Rowdy Friends Pet Stain & Odor Terminator
- Best for Urine: Nature’s Miracle Cat Stain and Odor Remover Spray
- Best Budget Enzymatic Cleaner: Biokleen Bac-Out Carpet Stain + Odor Remover
- Best for Odors: Zero Odor Pet Stain Remover & Odor Eliminator
- Best Eco-Friendly: Skout’s Honor Pet Stain & Odor Remover
- Best Scent: Angry Orange Ready-to-Use Citrus Pet Odor Eliminator Spray
- Best for Carpets: Carbona Oxy Powered Carpet Cleaner
- We Also Like: Rocco & Roxie Supply Co. Oxy Stain Remover
Best Overall Cat Urine Cleaner with Enzymes
Bubba’s Rowdy Friends Pet Stain & Odor Terminator
PHOTO: Amazon
Buy at: Amazon, Walmart, Bubbasrowdyfriends.com
Pros:
- Completely eliminates both new and old cat urine stains and odors.
- Pleasant, light mint and eucalyptus scent.
- Safe for use on various surfaces including rugs, upholstery, wood, and more.
- Carpet and Rug Institute approved.
- Refills available in gallon jugs.
Cons:
- Limited availability in physical stores.
In our tests, Bubba’s Rowdy Friends Pet Stain & Odor Terminator consistently outperformed other cleaners when tackling stubborn cat urine stains. We tested it on a set-in cat pee stain on a faux fur rug, and even weeks later, the odor did not return. Following the instructions, we saturated the stain with the undiluted cleaner for an hour, rinsed it with water, and air-dried the rug. Both the stain and the smell vanished completely, leaving a subtle, refreshing scent of mint and eucalyptus.
This product is an enzymatic cleaner, meaning it harnesses the power of enzymes—proteins that speed up chemical reactions. In this case, the enzymes work to break down the components of the stain, specifically targeting the ammonia crystals in cat urine that cause lingering odors. Enzymatic cleaners are highly effective for pet stains because they are designed to target the organic compounds found in urine, feces, and vomit. They are also generally safer and more environmentally friendly compared to cleaners with harsh chemicals.
Bubba’s Rowdy Friends proved effective on virtually any surface we tested, from carpets and upholstery to wood floors, concrete, plastic, laundry, and even artificial grass. Its certification from the Carpet and Rug Institute further confirms its cleaning efficacy and colorfastness. It’s available in a convenient 32-ounce spray bottle and larger gallon refills for economical use.
Cleaner Type: Enzymatic spray | Scent: Mint, eucalyptus | Safe Around Kids & Pets: Yes | Ingredients: Water, advanced biological blend, non-ionic surfactant, odor counteractant | Sizes: 32, 64, and 128 ounces
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PHOTO: The Spruce Pets / Danielle Directo-Meston
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PHOTO: The Spruce Pets / Danielle Directo-Meston
Best Cat Urine Cleaner with Enzymes for Urine
Nature’s Miracle Cat Stain and Odor Remover Spray
PHOTO: Chewy
Buy at: Amazon, Chewy, Walmart
Pros:
- Highly effective at removing both fresh and old cat urine stains.
- Easy-to-use spray bottle for targeted application.
- Light and pleasant citrus scent.
- Safe for carpets, rugs, hardwood floors, and more.
- Cruelty-free (no animal testing).
Cons:
- Not suitable for untreated hardwood, leather, suede, silk, or wool.
Nature’s Miracle Cat Stain and Odor Remover Spray is specifically designed to tackle the unique challenges of feline messes. This enzymatic cleaner effectively dissolves both new and old stains and odors caused by cat urine, feces, and vomit. Upon contact, the enzymes immediately begin to break down the organic matter, eliminating the mess and leaving a light citrus scent behind.
The spray bottle design makes application simple and precise, allowing you to saturate stains and odor hotspots effectively. In our testing, applying Nature’s Miracle to a fresh urine stain on beige carpet yielded impressive results. After a 15-minute wait, blotting the area revealed the yellow urine stain lifting onto the paper towel, visibly removing the discoloration.
This reasonably priced cleaner is versatile enough for use on water-safe surfaces like hardwood floors and upholstery. It’s important to keep pets away from treated areas during application and while the product is saturating the stain. Once dried and the stain and odor are gone, your pets can safely return to the area.
Cleaner Type: Enzymatic spray | Scent: Citrus | Safe Around Kids & Pets: Yes | Ingredients: Water, isopropyl alcohol, surfactants, citrus fragrance, enzymatic blend, odor counteractant | Sizes: 32 ounces
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PHOTO: The Spruce Pets / Jodi Espinosa
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PHOTO: The Spruce Pets / Jodi Espinosa
Best Budget Enzymatic Cat Urine Cleaner
Biokleen Bac-Out Carpet Stain + Odor Remover
PHOTO: Vitacost
Buy at: Amazon, Target, Biokleenhome.com
Pros:
- Free from phosphates, chlorine, ammonia, artificial fragrances, and dyes.
- Cruelty-free and not tested on animals.
- Effective stain and odor removal on various water-safe surfaces.
Cons:
- Squeeze bottle dispenser can be slow for large stains.
For an effective yet affordable cat urine cleaner with enzymes, Biokleen Bac-Out Carpet Stain + Odor Remover is an excellent choice. Enzymatic cleaners are particularly effective at breaking down the fats, proteins, and other compounds found in organic matter like pet urine, feces, and vomit. Biokleen Bac-Out performed comparably to our other top enzymatic cleaners in our tests.
This plant-based cleaner is formulated without harsh chemicals like phosphates, chlorine, and ammonia, and it’s also free of artificial fragrances and dyes. It can be safely used on most water-safe surfaces, including carpets, clothing, and upholstery. Testers noted a light, pleasant scent reminiscent of lemonade.
Biokleen Bac-Out provides exceptional value, being more budget-friendly than many other enzymatic cleaners. It’s also frequently available in two-packs, offering even greater savings for households dealing with frequent pet messes.
Cleaner Type: Enzymatic spray | Scent: Lemon | Safe Around Kids & Pets: Yes | Ingredients: Water, glycerin, viable bacteria culture, phenoxyethanol, C12-16 pareth-7, tetrasodium glutamate diacetate, disodium citrate, citrus species leaf oil | Sizes: 16, 32 ounces
Best Cat Urine Cleaner with Enzymes for Odors
Zero Odor Pet Stain Remover & Odor Eliminator
PHOTO: Amazon
Buy at: Amazon, Chewy, Walmart
Pros:
- Non-toxic and biodegradable formula.
- Safe for use on various surfaces like upholstery, carpets, and pet carriers.
- Tracer fragrance helps identify cleaned areas.
Cons:
- Initial chlorine-like scent, though it dissipates quickly.
When odor elimination is your primary concern, Zero Odor Pet Stain Remover & Odor Eliminator stands out. This powerful cleaner is designed to eradicate even the most persistent cat urine odors. Spray it directly onto stains or into the air to neutralize unpleasant smells effectively.
In our tests, Zero Odor impressed us with its ability to quickly remove both cat urine stains and odors from carpeting with just a single application. While the formula doesn’t leave a lasting fragrance, you might notice a faint chlorine-like scent briefly after application. This is a tracer fragrance, designed to help you identify areas you’ve already treated.
This cleaning product is safe for use around both humans and animals, although it’s always wise to keep children and pets away from freshly treated areas until they are dry. The manufacturer claims its odor-eliminating power is even strong enough to tackle skunk spray odors, although we didn’t test it for that specific scenario.
Cleaner Type: Enzymatic spray | Scent: Chlorine tracer fragrance | Safe Around Kids & Pets: Yes | Ingredients: Water, stabilized hydrated active complex, alcohol, pH balancer, tracer fragrance, surface tension agent | Sizes: 16 ounces
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The Spruce Pets / Giaco Furino
Best Eco-Friendly Cat Urine Cleaner with Enzymes
Skout’s Honor Pet Stain & Odor Remover
PHOTO: Chewy
Buy at: Amazon, Chewy, Walmart
Pros:
- Adjustable spray nozzle for targeted application.
- Effectively neutralizes odors, even in multi-cat households.
- Supports animal rescues through a portion of profits.
- Manufacturer guarantee and readily available contact information.
- Cruelty-free.
Cons:
- May require multiple applications for stain removal.
- Not for use on natural surfaces like wool and leather.
For environmentally conscious cat owners, Skout’s Honor Pet Stain & Odor Remover is an excellent eco-friendly enzymatic cleaner choice. It utilizes a plant-based surfactant to break down stains and a mineral-based deodorizer to neutralize pet odors. The adjustable spray nozzle allows for targeted application on carpets, furniture, bedding, and other water-safe surfaces.
We found Skout’s Honor particularly effective at neutralizing odors in a multi-cat litter box area. It eliminated strong urine and fecal odors, leaving a light floral fragrance that quickly dissipated. Being safe for use around pets, it’s a great option for regular cleaning.
While highly effective at odor neutralization, we observed that Skout’s Honor required several applications to noticeably improve older stains on rugs and sofas. It performed better on fresh stains and can also be used to clean up mud, grease, and wine. However, it’s not recommended for natural surfaces like wool, unsealed wood, and leather.
Beyond its cleaning efficacy and eco-friendly formula, Skout’s Honor is a company that gives back. A portion of every purchase supports animal rescues, and they offer a satisfaction guarantee with easily accessible contact information.
Cleaner Type: Enzymatic spray | Scent: Fresh | Safe Around Kids & Pets: Yes | Ingredients: Deionized water, biokore, biodegradable molecular complex, plant-based fragrance | Sizes: 35, 128 ounces
Best Scented Cat Urine Cleaner with Enzymes
Angry Orange Ready-to-Use Citrus Pet Odor Eliminator Spray
PHOTO: Amazon
Buy at: Amazon, Chewy, Walmart
Pros:
- Delightful light citrus scent derived from natural oranges.
- Paraben-free, sulfate-free, and phthalate-free formula.
- Effectively eliminates detectable odors overnight.
- Versatile use on various surfaces including carpets, furniture, and car interiors.
- Available in ready-to-use spray and concentrated formula.
Cons:
- Spray nozzle may occasionally jam.
- May require multiple applications for set-in stains.
If you prefer a cat urine cleaner with enzymes that leaves behind a pleasant scent, Angry Orange Ready-to-Use Citrus Pet Odor Eliminator Spray is an excellent option. This cleaner utilizes the natural power of oranges to eliminate tough pet odors. Testing it on a cat urine stain on a couch, we were greeted the next morning with a refreshing orange aroma, reminiscent of freshly peeled oranges. The stain itself was also significantly reduced, with only a faint outline remaining.
Originally developed for use in farms and kennels, this cleaner is safe for homes with pets and children. It’s available in a ready-to-use spray and a concentrated formula that can be diluted with water. Angry Orange is effective on hardwood floors, tile, upholstery, car interiors, and more.
Cleaner Type: Enzymatic spray | Scent: Citrus | Safe Around Kids & Pets: Yes | Ingredients: Water, orange fragrance, proprietary encapsulated 5-strain bacillus blend, nonionic surfactant, sodium citrate, benzylisothiazolinone, d-limonene, linalool | Sizes: 2, 24, and 128 ounces
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The Spruce Pets / Danielle Directo-Meston
Best Cat Urine Cleaner with Enzymes for Carpets
Carbona Oxy Powered Carpet Cleaner
PHOTO: Amazon
Buy at: Amazon, Walmart, Ace Hardware
Pros:
- Convenient built-in brush applicator.
- Effectively removes fresh stains quickly.
- Fragrance-free formula.
Cons:
- May require multiple applications for set-in stains.
Carbona Oxy Powered Carpet Cleaner is designed specifically for carpets and features a unique built-in brush to aid in stain removal. While not strictly an enzymatic cleaner, it utilizes oxygen power to lift stains and is effective at removing cat urine stains, especially when fresh.
In our testing, we were impressed by how quickly and easily Carbona removed fresh stains. However, set-in stains required multiple applications. We found that blotting stains before applying the spray foam was particularly helpful. Wet stains were removed within six minutes, while dried stains took around 12 minutes to disappear completely.
Carbona Oxy Powered Carpet Cleaner is fragrance-free, which is ideal for those sensitive to scents. However, it doesn’t completely eliminate urine odor on its own. After removing the visible stain, we recommend following up with an enzymatic cleaner to fully eliminate odors and prevent re-marking.
Cleaner Type: Liquid foam | Scent: Fragrance-free | Safe Around Kids & Pets: Yes | Ingredients: Aqua. sodium ethylhexylsulfate, alcohols (c13 and branched), ethoxylated, hydrogen peroxide, parfum, ethylhexanol, diethylenetriamine, pentamethylene phoshonic acid, magnesium chloride, sodium gluconate, sodium hydroxide, benzisothiazolinone, methylisothiazolinone | Sizes: 27.5 ounces
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PHOTO: The Spruce Pets / Henry Wortock
We Also Like: Rocco & Roxie Supply Co. Oxy Stain Remover
PHOTO: Amazon
Buy at: Amazon, Chewy, Walmart
Pros:
- Appealing sweet mint scent.
- Effective on older, set-in stains.
- Versatile cleaner for various stain types beyond pet messes.
- Cruelty-free.
Cons:
- Darker stains may require multiple treatments.
Rocco & Roxie Supply Co. Oxy Stain Remover is a reliable and versatile spray cleaner ideal for tackling a wide range of stains and odors, including cat urine. While we focused our testing on pet-related stains and odors on rugs and upholstery, this cleaner is also effective for pet kennels, carriers, litter boxes, clothing, and bedding.
It effectively removed both wet and dry pet stains in our tests. While heavier stains might need a second application, we successfully removed set-in urine, red wine, and mud stains. It’s chlorine-free and color-safe, certified by the Carpet and Rug Institute, so you can use it without fear of damaging or discoloring surfaces. Rocco & Roxie products are made in the USA and are safe to use around pets and children.
Cleaner Type: Enzymatic spray | Scent: Fragrance-free | Safe Around Kids & Pets: Yes | Ingredients: Water, hydrogen peroxide, sodium laurel ether sulfate, proprietary ethoxylated alcohol, d-limonene, potassium pyrophosphate | Sizes: 32 ounces
[:max_bytes(150000):strip_icc()/SPRPets_RoccoandRoxieOxyStainRemoveratAmazon_HW_13-6c23eff5135f48da9dad18b95de636ce.jpg)](https://www.thesprucepets.com/thmb/44enXq5VZrgAQMirT3aOl02uBeM=/750×0/filters:no_upscale():max_bytes(150000):strip_icc()/SPRPets_RoccoandRoxieOxyStainRemoveratAmazon_HW_13-6c23eff5135f48da9dad18b95de636ce.jpg)
The Spruce Pets / Henry Wortock
Final Verdict on the Best Cat Urine Cleaner with Enzymes
For the best overall cat urine cleaner with enzymes, we recommend Bubba’s Rowdy Friends Pet Stain & Odor Terminator. It’s effective on various surfaces, tackles both stains and odors, and is reasonably priced. If you prefer a cleaner with a pleasant scent, Angry Orange Pet Odor Eliminator Spray is a great choice, replacing cat urine odors with a fresh orange aroma.
Other Cat Urine Cleaner with Enzymes Products We Considered
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Skout’s Honor Litter Box Deodorizer: This mineral-based formula quickly eliminates odors in and around litter boxes and on soft surfaces.
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Kids ‘N’ Pets Instant All-Purpose Stain & Odor Remover: A non-toxic formula that deters repeat marking by eliminating lingering urine odors on various water-safe surfaces.
How We Tested Cat Urine Stain and Odor Removal Products
We conducted rigorous testing of 27 stain and odor removal products in our Des Moines Lab. Each product was applied to both fresh and set-in stains on carpeted rugs and upholstery fabric to assess their effectiveness. Our testing methodology involved scoring products across multiple criteria and gathering subjective impressions throughout the process.
From these initial tests, we selected 17 top-performing products for real-world testing in homes with cats. Over two weeks, volunteer testers provided feedback on each cleaner’s ease of use, stain and odor removal effectiveness, and scent.
Finally, we analyzed all collected data to rank and categorize our top picks, helping cat owners find the best cat urine cleaner with enzymes for their specific needs.
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The Spruce Pets / Henry Wortock
What to Look for in a Cat Urine, Odor, and Stain Removal Product
When choosing a cat urine cleaner with enzymes, consider these key factors:
Active Ingredients
Different cleaners utilize various active ingredients. While some rely on chemicals, enzymatic cleaners use natural enzymes to break down stains and odors. Always check the label, especially if you have children or other pets. Enzymatic cleaners are often preferred for their safety and effectiveness in deterring re-marking.
Color-Safe Testing
Many cleaners claim to be “color-safe,” but it’s always best to test any product on a hidden area first to ensure it doesn’t affect the color or fabric.
FAQ about Cat Urine Cleaner with Enzymes
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What is an enzymatic cleaner?
Enzymatic cleaners contain beneficial bacteria that produce enzymes to break down organic materials like pet urine. These enzymes break down molecules into smaller pieces, which the bacteria then consume, eliminating the stain and odor. -
How do I remove old or set-in pet stains from carpet?
Use a high-quality cat urine cleaner with enzymes and carefully follow the product instructions. Set-in stains may require multiple applications and manual agitation (using gloves, a brush, or cloth) to help the cleaner penetrate the carpet fibers. -
Can dry cleaning remove cat urine odors?
No, dry cleaning alone won’t eliminate cat urine odors. While it can remove the stain and temporarily mask the smell, cat urine contains uric acid that can persist for years. Only enzymatic cleaners can effectively break down uric acid and permanently remove the odor.
Why Trust The Spruce Pets
This article was updated by Anna Mejorada, a writer for The Spruce Pets, and pet owner familiar with the challenges of pet messes. We combine lab testing and real-world trials to provide trustworthy and helpful product recommendations for pet owners. A previous version was written by Anne Fritz, a home content expert. We are committed to providing well-researched and reliable information to help you care for your pets and home.
